Acute on chronic liver failure in a patient with sickle cell anaemia (HbSS)

Liver transplantation in a patient with acute liver failure due to sickle cell intrahepatic cholestasis.

BACKGROUND Sickle cell intrahepatic cholestasis is a potentially catastrophic complication of sickle cell anemia Once acute liver failure develops, transplantation is the only option. We describe a patient with sickle cell intrahepatic cholestasis who underwent liver transplantation. METHODS Data were obtained from the chart. Serial hemoglobin S levels were monitored, and measures were taken ...

Rhabdomyolysis and acute renal failure in sickle cell anaemia.

A 25 year old Nigerian man presented with a three day history of a painful right knee, abdominal pain, diarrhoea, vomiting, and fever. Previously healthy, he had been admitted to hospital only once before suffering from sickle cell crisis. Examination showed he was drowsy but well orientated. His temperature was 38 5-C and he was moderately dehydrated with a blood pressure of 110/70 mm Hg, both...

Severe malarial infection in a patient with sickle-cell anaemia.

Effect of Lisinopril on Microalbuminuria in Sickle Cell Anaemia Children: A Single-Blind Randomized Controlled Trial

Background Sickle cell nephropathy is a major cause of morbidity and mortality in sickle cell anaemia (SCA). Proteinuria contributes to progression of renal damage. Icroalbuminuria is an early feature of SCN and progression to advanced kidney damage is delayed if regression is achieved with angiotensin converting enzyme inhibitors. We aimed to ...

[Acute on chronic liver failure].

Acute-on-Chronic Liver Failure (ACLF) is a recently introduced term defined as severe acute deterioration of an established liver disease. This entity usually develops after an acute insult. The main clinical manifestations are hepatorenal syndrome, hepatic encephalopathy and organ failure, with a high risk of death in the short term. The true incidence of ACLF remains difficult to determine du...